Characterization and antibacterial activity of biosynthesized silver nanoparticles derived from a saprophytic fungal isolate

Antimicrobial resistant becomes a major factor virtually in all hospitals acquired infection may soon be untreatable; it leads to cause serious public health problem. These concerns have led to major research effort to discover alternative strategies for the treatment of bacterial infection. Nanobiotechnology is an upcoming and fast developing field with potential application for human welfare. In the recent scenario, progress in nano-biotechnology research has made a great development particularly in the field of medicine based on metallic nanoparticles with antibacterial property to combat the pathogenic bacteria, who are resistance to varied antibiotics. Silver nanoparticles have their own advantages in order to kill the microbes effectively. In the present study, we have reported the biological synthesis of silver nanoparticles (AgNPs) from airborne saprophytic fungus; Aspergillus sp. isolated from the indoors of our laboratory. Bioreduction of Ag+ was observed when fungal extract was augmented with AgNO3 and kept at different reaction conditions (temperature and pH). The formation of silver nanoparticles was confirmed by surface plasmon resonance as determined by UV-Vis spectra at 425nm. These AgNPs were found to possess potential antibacterial activity against various gram +/bacterial pathogens. Biological approach of airborne wild fungus would be the novel way towards the development of safe, cost effective and environmental friendly method for the green synthesis of silver nanoparticles and thus synthesized AgNPs would be used in several areas of medicine.